Sep 1, - Congenital masses, such as branchial anomalies and thyroglossal duct cysts, must be considered in the differential diagnosis. Neoplasms (benign and malignant) are more likely to be present in older adults. When an adult patient presents with a neck mass, malignancy is the greatest concern. Apr 23, - Neck lumps or masses can be large and visible, or they can be very small. Most neck lumps aren't harmful. Most are also benign, or noncancerous. But a neck lump can also be a sign of a serious condition, such as an infection or a cancerous growth.Pictures of neck lumps · Origin · Causes · Associated symptoms.